Consolidated Statement of Movement in Shareholders' Funds
for the Year Ended December 31, 1997

Class 'A' Ordinary Shares Class 'B' Ordinary Shares
Share Share
capital capital Premium
Number of IR£0.01 Number of IR£0.01 in excess Retained Currency Goodwill Treasury
shares each shares each of par deficit adjustment reserve shares Total Total
IR£ IR£ IR£ IR£ IR£ IR£ IR£ IR£ US$
Authorised 50,000,000 500,000 700,000 7,000
________ ________ ________ ________
Issued:
Balance as at December 31, 1994		 9,317,151 93,171 700,000 7,000 13,119,775 (4,975,852 ) (69,911 ) (6,928,342 ) (419,287 ) 826,554 1,175,360
________ ________ ________ ________ ________ ________ ________ ________ ________ ________ ________
Shares issued for cash 96,953 970 - - 89,030 - - - - 90,000 127,980
Private placement of Class 'A' shares for cash (note 17 (c)) 4,284,713 42,847 - - 4,225,601 - - - - 4,268,448 6,069,733
Options exercised 882,000 8,820 - - 313,370 - - - - 322,190 458,154
Issue of shares for services 35,000 350 - - 24,479 - - - - 24,829 35,307
Fair value adjustment to goodwill arising on acquisition of FHC - - - - - - - (6,569 ) - (6,569 ) (9,342 )
Share issue expenses - - - - (506,884 ) - - - - (506,884 ) (720,789 )
Currency adjustment - - - - - - (47,398 ) - - (47,398 ) (67,400 )
Profit and loss account - - - - - (519,129 ) - - - (519,129 ) (738,201 )
Disposal of treasury shares - - - - - 60,313 - - 174,703 235,016 334,193
________ ________ ________ ________ ________ ________ ________ ________ ________ ________ ________
Balance as at December 31, 1995 14,615,817 146,158 700,000 7,000 17,265,371 (5,434,668 ) (117,309 ) (6,934,911 ) (244,584 ) 4,687,057 6,664,995
_________ ________ ________ ________ ________ ________ ________ ________ ________ ________ ________
Shares issued for cash 205,735 2,057 - - 209,145 - - - - 211,202 300,330
Options exercised 589,211 5,892 - - 527,737 - - - - 533,629 758,821
Class 'A' Warrants exercised 188,086 1,881 - - 351,024 - - - - 352,905 501,831
Goodwill arising on acquisition of product line - - - - - - - (118,042 ) - (118,042 ) (167,856 )
Share issue expenses - - - - (50,977 ) - - - - (50,977 ) (72,490 )
Currency adjustment - - - - - - (21,601 ) - - (21,601 ) (30,717 )
Profit and loss account - - - - - (468,204 ) - - - (468,204 ) (665,786 )
Disposal of treasury shares - - - - - 877,994 - - 244,584 1,122,578 1,596,306
________ ________ ________ ________ ________ ________ ________ ________ ________ ________ ________
Balance as at December 31, 1996 15,598,849 155,988 700,000 7,000 18,302,300 (5,024,878 ) (138,910 ) (7,052,953 ) - 6,248,547 8,885,434
_________ ________ ________ ________ ________ ________ ________ ________ ________ ________ ________
Shares issued for cash 175,548 1,755 - - 218,245 - - - - 220,000 312,841
Class 'A' Shares issued for the purchase of Clark Laboratories (note 17 (d)) 1,427,142 14,272 - - 2,366,183 - - - - 2,380,455 3,385,007
Class 'A' Shares issued for the purchase of  financial asset (note 17 (d)) 153,202 1,532 - - 254,006 - - - - 255,538 363,375
Class 'A' Warrants exercised 396,065 3,961 - - 814,659 - - - - 818,620 1,164,078
Options exercised 4,440,965 44,410 - - 3,017,856 - - - - 3,062,266 4,354,542
Goodwill arising on acquisition of Clark - - - - - - - (4,394,639 ) - (4,394,639 ) (6,249,177 )
Goodwill arising on acquisition of Centocor - - - - - - - (4,217,609 ) - (4,217,609 ) (5,997,440 )
Share issue expenses - - - - (321,113 ) - - - - (321,113 ) (456,623 )
Currency adjustment - - - - - - 94,518 - - 94,518 134,405
Profit and loss account - - - - - 849,697 - - - 849,697 1,208,269
________ ________ ________ ________ ________ ________ ________ ________ ________ ________ ________
Balance as at December 31, 1997 22,191,771 221,918 700,000 7,000 24,652,136 (4,175,181 ) (44,392 ) (15,665,201 ) - 4,996,280 7,104,711
_________ ________ ________ ________ ________ ________ ________ ________ ________ ________ ________

See Notes to Consolidated Financial Statements

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